Computational Biologist 2


Job title: Computational Biologist 2

Company: Oregon Health & Science University

Job description: Function/Duties of Position

Our focus on early detection requires novel approaches to reliably identify small/rare signals in diverse data types, with an emphasis on minimally invasive sampling techniques. In this role you would work project teams that include CEDAR scientists such as Gurkan Yardimci, Hisham Mohammed, Andrew Adey and Xiaolin Nan initially and with increasing collaboration over time: We are currently hiring at the level of Computational Biologist 3 with expertise in Computational Biology to work in the following areas:

  • Machine Learning/Statistics – Developing machine learning methods and/or statistical models to study the organization of the epigenome and three dimensional structure of the genome using cutting edge genomics and super resolution microscopy datasets. Developed algorithms will be used to deeply characterize cell populations and identify features that are indicative of cell state. Techniques such as (but not limited to) dimensionality reduction, clustering, and predictive modeling will be utilized.
  • Genomics/single cell genomics Modeling and analyzing next-generation sequencing datasets that measure the transcriptome and the epigenome, with an emphasis on the single-cell variants, such as single cell RNA-seq and single cell ATAC-seq. The successful candidate will use both existing tools and develop their own computational methods to analyze such datasets for characterization of healthy and cancerous cell populations.
  • Multiomics– Developing computational methods for the analysis of single-cell multiomics technologies that are able to characterize multiple “omes” of a single cell concurrently, such as the epigenome and the transcriptome (see references below). These methods will be utilized for deep characterization of healthy and cancerous cells and investigate the links between the transcriptome, the epigenome and 3D conformation of chromatin.

Select references:

  • https://www.nature.com/articles/s41586-019-1825-8
  • https://science.sciencemag.org/content/361/6409/1380
  • https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008173

Duties Include:

  • Team Science: Collaborate on teams and/or lead teams on the identification of scientific problem, design of approach to address it, and identification, acquisition and management of resources to perform investigations. Foster and support teamwork. Provide training and guidance to fellow researchers and staff.
  • Laboratory Research Project Management: Independently develop and manage research experiments, determining the most suitable methods to be used. Interpret and perform complex data analysis on experimental results and determine whether they are consistent with goals. Ensure that research team members maintain accurate and detailed records of all experimental procedures, data collections and analysis performed. Maintain a high level of professional expertise through familiarity with current scientific literature. As needed, develop innovative techniques and experimental systems to meet research program goals.
  • Scientific Writing and Project Proposal Development: Prepare research findings for presentation at scientific meetings and conference and manuscripts for publication. Prepare research project proposals for internal review, prepare annual or bi-annual research progress summaries and presentations for CEDAR scientists and staff.
  • Laboratory Organization and Compliance: Develop and implement procedures and systems to maximize the organization and efficiency within designated projects. Mentor and train lab members on lab practices and protocols. Ensure that staff is adequately trained to meet compliance for regulatory board reviews as required. Aid in the submission of specific protocols to the Institutional Review Board and other regulatory review boards.
  • Collaborative Interactions: Develop, foster and maintain relationships with partners in academia and in the pharmaceutical/biotechnology industries.

Required Qualifications

  • PhD in Computational Biology or related field OR Master’s Degree in Computational Biology or related field AND 6 years of relevant experience OR Equivalent combination of training and experience
  • Those with a Master’s Degree in Computational Biology or related field AND 3 years of relevant experience OR Bachelor’s Degree in Computational Biology or related field AND 6 years of relevant experience OR Equivalent combination of training and experience will be considered at the Research Associate level
  • Major coursework in the one of the following ares: computational biology, statistics, computer science or machine learning
  • Programming experience with python/R or equivalent programming languages
  • Experience in working with existing software for the analysis of next generation sequencing genomics data such as RNA-seq, ATAC-seq and Hi-C, including their single-cell versions
  • Strong background in machine learning or statistics
  • Excellent communication, analytical and organizational skills
  • Ability to work independently and as part of a team while being collaborative in resolving problems
  • Satisfactory publication record
  • Demonstrated ability to learn new and innovative processes quickly
  • Must possess energy and drive to coordinate multiple projects simultaneously
  • Ability to use tact and diplomacy to maintain effective working relationships

Preferred Qualifications

  • PhD and 2+ years of experience, MS and 5+ years of experience, or BS and 10+ years of experience
  • Background in one and more of following topics: mixture modeling, deep learning, dimensionality reduction
  • Track record of developing computational methods for modeling and analyzing genomics datasets
  • Ability to clearly communicate and collaborate with researchers from diverse backgrounds, including wet-lab scientists
  • Expertise in early cancer detection
  • Experience in a collaborative or team science based environment
  • Experience in user friendly software development, maintenance , and version control

Additional Details

Apply online. Please be sure to upload a Cover Letter and Resume/CV.

All are welcome

Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or aaeo@ohsu.edu.

As an organization devoted to the health and well-being of people in Oregon and beyond, OHSU requires its employees to be fully vaccinated against COVID-19.

Expected salary: $68100 – 113000 per year

Location: Portland, OR

Job date: Wed, 02 Feb 2022 04:05:46 GMT

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